EARTH: Betty becomes Hulk instead of Bruce
Red She-Hulk #66
An alternate timeline where Betty saves Bruce from the Gamma Bomb explosion and she becomes a savage red hulk. Bruce works with her to stabilize her transformation into one more like that in Earth: Marvel. In this form, she goes on to join the Avengers, eventually falling in love with Thor. Bruce, heartbroken, helps to create both Sentinels and an army of Machine Men to destroy superhumans.